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Montair 4mg Tablet 1 Strip
Montair is recommended for the following conditions:
- Long-term prevention and treatment of asthma
- Acute prevention of exercise-induced bronchospasm (EIB)
- Relief from symptoms of allergic rhinitis—both seasonal and perennial types
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✅ Description:
Montelukast is a selective leukotriene receptor antagonist that blocks the CysLT1 receptor, responsible for mediating inflammation. Leukotrienes (LTC4, LTD4, LTE4)—produced from arachidonic acid by mast cells and eosinophils—play a key role in asthma and allergic rhinitis symptoms like airway swelling, smooth muscle contraction, and inflammation. By inhibiting these effects, Montelukast helps reduce the severity of symptoms associated with these respiratory conditions.
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✔️ Dosage & Administration
Adults and Adolescents (≥15 years):
- 10 mg once daily for asthma or seasonal allergic rhinitis.
Pediatric Dosage:
- 6 to 14 years: 5 mg once daily
- 2 to 5 years: 4 mg once daily
- 6 months to 5 years (oral granules): 4 mg once daily
Can be given directly, or mixed with cold soft food or water.
Special Populations:
- Hepatic Impairment: No dose adjustment required in mild to moderate cases
- Renal Impairment: Dose adjustment is not necessary
- Elderly: Similar pharmacokinetics to younger adults; no dose change needed
✔️ Side Effects
Common: Headache, nausea, vomiting, diarrhea, fever, GI discomfort, upper respiratory tract infection, skin rash.
Uncommon: Anxiety, dizziness, sleep disturbances, dry mouth, joint pain, mood changes, muscle aches.
Rare: Suicidal thoughts, memory issues, liver problems, hallucinations, angioedema, eosinophilic granulomatosis, tremors.
✔️ Drug Interactions
Montair has shown no significant interactions with commonly used asthma medications or agents like theophylline, prednisone, oral contraceptives, terfenadine, digoxin, and warfarin.
Montair can be co-administered safely with thyroid hormones, NSAIDs, sedatives, benzodiazepines, and decongestants.
However, Phenobarbital may reduce Montair’s plasma levels by about 40%. Clinical monitoring is advised when co-administered with enzyme inducers such as rifampin or phenobarbital.
✔️ Contraindications
Hypersensitivity to Montelukast or any of its components.
✔️ Pregnancy & Lactation
Pregnancy: Although animal studies show placental transfer, human data is lacking. Use only when necessary.
Breastfeeding: Caution is advised as Montelukast may be excreted in breast milk.
✔️ Precautions & Warnings
- Not suitable for treating acute asthma attacks. Rescue inhalers should be readily available.
- Do not abruptly replace inhaled or oral corticosteroids with Montair.
- Not intended for monotherapy in exercise-induced bronchospasm.
- Aspirin-sensitive patients should continue avoiding NSAIDs and aspirin even while on Montair.
✔️ Storage Instructions
- Store below 30°C, in a cool, dry place, away from light and moisture.
- Keep out of reach of children.
